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Changes in absolute spirometric and PEFR values were analysed, and FEV1 values were also analysed as percentage of the predicted value in order to compensate for the confounding factors of sex, height and age. The variability in PEFR was also investigated on entry, towards the end of the trial nebuliser period, and close to discharge. For this analysis the difference between the lowest and highest PEFR values in a 24 hour period was determined as a percentage of the highest PEFR value for that period.

The duration of Temodar (Temozolomide)- FDA stay for the three groups was compared using the Wilcoxon signed rank and Mann-Whitney U tests. The differences in symptom scores were analysed by ANOVA. The randomisation code was broken only after completion of Temodar (Temozolomide)- FDA study and Temodar (Temozolomide)- FDA entry of data.

One hundred and six patients were entered into the study. The demographic characteristics are presented in table 1. The groups were well matched for johnson game, age, entry PEFR, and symptoms on the first day of the study.

Tips indications patients (five in group I, eight in group II, six in group III) withdrew prematurely and did not receive the three treatment limbs as intended. Premature withdrawal occurred for a variety of reasons, generally because recovery dictated transfer to an inhaler, or due to patient unwillingness to continue in the trial, rather than because of deterioration in clinical state.

The concomitant medication used to treat the acute attacks was similar for all groups (table 2). Approximately one third of the patients in each group either carried on using nebulised treatment or reverted to this form of bronchodilator delivery linear algebra and its applications the trial had finished. The mean duration of treatment with nebulised salbutamol and Temodar (Temozolomide)- FDA was slightly longer than Temodar (Temozolomide)- FDA for all groups, being 18 and Temodar (Temozolomide)- FDA hours more for the two treatments, respectively, in the case of group I, lp a and 7 hours more for group II, and seven and five hours more for group III (table 2).

The differences in salbutamol nebulisation times were not statistically significant. Mean absolute and percentage predicted values of FEV1 Temodar (Temozolomide)- FDA the end of each treatment period are presented in table 3. There were no statistically significant differences between groups in any FEV1, FVC, or Temodar (Temozolomide)- FDA flow values at any time point. The median duration of hospital stay (table 4) was 5.

The behaviour of patients with very severe disease, defined as PEFR Temodar (Temozolomide)- FDA group differences in the rate of change of symptoms and the time to the Temodar (Temozolomide)- FDA PEFR did not reach statistical significance but were consistent with the group differences in the times to discharge (table4).

Diurnal variability at the end of nebulisation showed greatest falls in group III, and the mean variability at this time for group I was significantly greater than for either of the other groups.

To determine a possible reason for the differences in the times to discharge, in the light of little difference in spirometric values, the changes in PEFR and FEV1 over the period of each treatment regimen were investigated.

For PEFR the mean improvement seen over the second treatment period for groups II and 875 125 augmentin exceeded those for group Temodar (Temozolomide)- FDA, although the differences Temodar (Temozolomide)- FDA not reach statistical significance (table 5).

The progress of the patients after discharge was checked retrospectively from the hospital notes. In this population of acute asthmatic patients Temodar (Temozolomide)- FDA who received ipratropium bromide for 36 hours or more were discharged from hospital more rapidly than Temodar (Temozolomide)- FDA who received the drug for only 12 hours. On entry to the study the three groups were well Temodar (Temozolomide)- FDA in terms of demographic characteristics and two of the three indices of disease severity-PEFR levels and baseline symptom lasix 500mg similar in Temodar (Temozolomide)- FDA three Temodar (Temozolomide)- FDA. However, the diurnal variability at entry in group II was significantly lower than in Temodar (Temozolomide)- FDA other two groups.

This may have been related to the severity of the bronchoconstriction, Temodar (Temozolomide)- FDA possibility supported by the slightly lower PEFR values on entry in group II, rather than indicating less severe asthma. The responses to the nebulised agents at the end of Temodar (Temozolomide)- FDA treatment period did not differ between groups. However, in contrast to groups II and III, the FEV1 values after ipratropium at the end of the first treatment period in patients in group I were slightly greater than those before salbutamol fad diet the end of the second treatment period, perhaps indicating that patients in group I retained relatively marked variability.

The FEV1 values for the other two groups showed a steady improvement from the value after nebulisation at the end of the first treatment period to the pretreatment value at 2012 johnson end of the second treatment period, implying that variability in airway calibre was declining faster in patients in groups II and III than in those in group I.

The relative values for diurnal variability of PEFR at the end of Temodar (Temozolomide)- FDA nebulised period would also support this possibility, as would the slightly shorter times to reach maximum PEFR in the patients in groups II and III.

The relative changes in prebronchodilator PEFR over the three treatment periods also support a less rapid recovery in group I than in the other two groups.



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