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Treatment What kinds of doctors treat pernicious anemia. What is the treatment for pernicious anemia and Succimer (Chemet)- FDA B-12 deficiency. Can it be cured. Center Pernicious Anemia and Vitamin Succimer (Chemet)- FDA Deficiency Center Comments Patient Comments: Pernicious Anemia - Symptoms Patient Comments: Pernicious Anemia - Treatments Patient Comments: Pernicious Anemia - Share Your Experience Patient Comments: Pernicious Anemia - Causes More Find a local Hematologist in your town Pernicious anemia definition and factsPernicious anemia is a condition in which a peron's red blood cell count is low because of a vitamin B12 deficiency.

Before doctors learned that pernicious anemia could be treated with vitamin B12, many people died from the condition. What is pernicious anemia. Anemia is a condition in which the body does not have a sufficient number of red blood cells or hemoglobin. Hemoglobin is present within red blood cells and is important for carrying oxygen to all tissues of the body. In males, anemia is typically defined as hemoglobin level of less than 13.

These definitions may vary slightly depending on the source and the laboratory reference used. Pernicious is a term that means destructive, injurious or deadly.

Anemia can result driving disruptions in the production of red blood cells or hemoglobin as well as from an increased destruction of red blood cells or loss of blood. It was termed "pernicious" because before it was learned that vitamin B-12 could treat the anemia, most people that developed the disease died from it.

Pernicious anemia is due to an inability to absorb vitamin B-12 (also known as cobalamin or Cbl) from the gastrointestinal tract. The body is able to store vitamin B-12 for a long time, so inadequate dietary intake must persist for years before a true deficiency of vitamin B-12 is reached. Therefore, the symptoms of pernicious anemia usually do not appear for years.

While pernicious anemia is most commonly diagnosed in Succimer (Chemet)- FDA with an average age of 60, a rare, congenital (inborn) type of pernicious anemia has been described. As with other causes of anemia, symptoms related to decreased oxygen-carrying capacity of the blood Succimer (Chemet)- FDA include tiredness and shortness of breath.

Pernicious anemia is more common in Succimer (Chemet)- FDA persons Succimer (Chemet)- FDA northern European ancestry than in other racial groups.

Pernicious anemia also is termed Biermer's or Addison's anemia. Sometimes, anemias are subclassified based upon the size and microscopic appearance of the red blood Succimer (Chemet)- FDA. In this regard, pernicious anemia is a form of megaloblastic anemia. Megaloblastic anemia refers to an abnormally large type of red blood cell (megaloblast).

Megaloblasts are produced in the bone marrow when vitamin B-12 or folic acid levels are low. Megaloblastic anemia also can be caused by other disease of the bone marrow and can be a side effect of some cancer chemotherapy drugs. What causes pernicious anemia. Pernicious anemia is people on drugs an autoimmune disease, in which the body's own immune system mistakenly damages its own tissues.

It is believed that the decreased absorption of vitamin B-12 from the gastrointestinal tract in pernicious anemia results from the presence of an autoantibody against intrinsic factor (IF), a protein made in the stomach Succimer (Chemet)- FDA is necessary for the absorption of vitamin B-12. Normally, vitamin B-12 binds to intrinsic factor in the stomach, and this facilitates its absorption by the small intestine further along Megestrol Acetate (Megace)- Multum the digestive process.

Along with the autoimmune process that attacks the IF protein and lowers IF levels in stomach secretions, another autoimmune reaction against the stomach lining cells also occurs, resulting in a form of inflammation known as chronic atrophic gastritis. Pernicious anemia is sometimes associated with other autoimmune diseases such as Graves' diflucan one, Hashimoto's thyroiditis and vitiligo (depigmentation or blanching of skin areas).

No, pernicious anemia is one form of vitamin B-12 deficiency that results from the autoimmune process described previously. However, other causes of vitamin B-12 deficiency also can produce the same signs and symptoms as pernicious anemia.

Other potential causes of vitamin B-12 deficiency include surgical removal of the stomach or a portion of the stomach (total or partial gastrectomy), other gastrointestinal diseases such as celiac disease or Crohn's disease, infections of the gastrointestinal tract, longstanding use of acid-reducing medications, and poor nutrition.

Succimer (Chemet)- FDA discussed previously, true pernicious anemia results from an autoimmune condition that impairs absorption of Succimer (Chemet)- FDA vitamin B-12, resulting in vitamin B-12 deficiency.

Vitamin B-12 Succimer (Chemet)- FDA of any cause, Succimer (Chemet)- FDA pernicious anemia, will result in anemia and neurologic symptoms. Because the body has large stores of vitamin B-12, a deficiency takes many years to establish.

Vitamin B-12 deficiency affects the nervous system, leading to a variety of symptoms. Sometimes, these may be apparent before symptoms related to the anemia. Neurological symptoms vary and may be Succimer (Chemet)- FDA (meaning that these are symptoms that can be caused by a number of different conditions).

Feelings of numbness, tingling, weakness, lack of coordination, clumsiness, impaired memory, and personality changes can all occur. Both sides of the body are usually affected, and the legs are typically more affected than the arms. A severe deficiency can result in more serious neurological symptoms, including severe weakness, spasticity, paraplegia, and fecal and urinary incontinence. Symptoms of anemia are due to the reduced oxygen-carrying capacity of the blood.

Shortness of breath, fatigue, dizziness, and pale skin can all occur with anemia. In anemia, the heart is placed under stress since it has to work harder to deliver enough oxygen to body tissues. This can result in heart murmurs, fast heartbeats, arrhythmias, an enlarged heart (cardiomegaly), or even heart failure. It is important to note that not all people who have vitamin B-12 deficiency and neurological symptoms also will have anemia.

A deficiency of vitamin B-12 also can alter the surface of the tongue, making Succimer (Chemet)- FDA appear shiny or smooth. Finally, sometimes pernicious anemia is diagnosed in a patient with no symptoms.

In these cases, it is usually found incidentally when blood tests are ordered for another reason. What kinds of doctors treat pernicious Succimer (Chemet)- FDA. Pernicious anemia may be treated by internal or family medicine specialists as well as specialists in disorders of the blood (hematologists).



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